Malaria and HIV infection in pregnancy are associated with reduced transfer of 1 antimalarial antibodies to the newborn 2 Running title : Malaria , HIV and transplacental antibodies
نویسندگان
چکیده
Laura Moro, Azucena Bardají, Tacilta Nhampossa, Inacio Mandomando, Elisa Serra-Casas, 4 Betuel Sigaúque, Pau Cisteró, Virander S. Chauhan, Chetan E. Chitnis, Jaume Ordi, 5 Carlota Dobaño, Pedro L. Alonso, Clara Menéndez, and Alfredo Mayor 6 7 1 Barcelona Centre for International Health Research (CRESIB), Hospital ClínicUniversitat de 8 Barcelona, Spain; 2 Centro de Investigaçao em Saúde da Manhiça (CISM), Manhiça, 9 Mozambique; 3 Instituto Nacional de Saúde, Ministry of Health, Maputo, Mozambique; 4 10 International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India; and 11 5 Department of Pathology, Hospital ClínicUniversitat de Barcelona, Spain. 12
منابع مشابه
Malaria and HIV infection in Mozambican pregnant women are associated with reduced transfer of antimalarial antibodies to their newborns.
BACKGROUND Malaria and human immunodeficiency virus (HIV) infection during pregnancy affect the transplacental transfer of antibodies against several pathogens from mother to fetus, although the effect of malaria and HIV infection on the transfer of antimalarial antibodies remains unclear. METHODS Levels of total immunoglobulin G (IgG), immunoglobulin M (IgM), and IgG subtypes against the fol...
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Over 35% of children in a region of malaria endemicity are infected with Epstein-Barr virus (EBV) by 6 months of age. This susceptibility may be linked to impaired transplacental transfer of antibodies. In this study, we determined the effect of malaria exposure during pregnancy on the transfer of EBV-specific maternal antibodies in a region of western Kenya that experiences endemic malaria. Pr...
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INTRODUCTION Young infants are protected from measles infection by maternal measles antibodies. The level of these antibodies at birth depends on the level of antibodies in the mother and the extent of placental transfer. We investigated predictors of levels of measles antibodies in newborns in rural Kenya. METHODS A total of 747 paired maternal-cord serum samples (91 from human immunodeficie...
متن کاملReduction of antimalarial antibodies by HIV infection is associated with increased risk of Plasmodium falciparum cord blood infection.
BACKGROUND Plasmodium falciparum infection in pregnancy can lead to congenital malaria, which has detrimental health consequences for infants. Human immunodeficiency virus (HIV) might increase cord blood P. falciparum infection by decreasing maternal antimalarial-specific antibodies. METHODS HIV-negative (n=133) and HIV-positive (n=55) Mozambican pregnant women were assessed at delivery for m...
متن کاملEffect of placental malaria and HIV infection on the antibody responses to Plasmodium falciparum in infants.
BACKGROUND Placental malaria (PM) and maternal infection with human immunodeficiency virus (HIV) type 1 have been shown to affect infant morbidity and immune responses to Plasmodium falciparum. We studied the effects of PM and HIV infection on the antimalarial antibody responses and morbidity outcomes of infants throughout the first year of life. METHODS A total of 411 Kenyan infants who were...
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